Public Health and Primary CareCLINICAL PRACTICE

Hemolytic Uremic Syndrome Caused by Shiga Toxin–Producing Escherichia coli 0111

Reza Azadi, DO; Kenneth Calabrese, DO; and Jeffrey Stroup, PharmD
Notes and Affiliations
Notes and Affiliations

Received: June 15, 2009

Accepted: April 30, 2010

Published: September 1, 2010

J Osteopath Med; 110(9): 538-544

Shiga toxin–producing Escherichia coli (STEC) was first discovered in 1977 and since has caused serious complications including the life-threatening condition of hemolytic uremic syndrome (HUS). While HUS is most common in children, adults and especially elderly patients experience a higher incidence of death and disability. Because the majority of HUS cases have been described in children, pediatric treatment options have been used to treat adult and elderly patients with HUS. More research regarding the treatment, risk factors, and prognosis of HUS in adults needs to be performed to ensure that optimal care is provided. The authors present a case series of 5 adults with HUS who were part of the largest outbreak of E coli 0111 reported in the United States. To date, there are no published cases of HUS secondary to E coli 0111 in adults. The authors also include a literature review of HUS secondary to STEC.

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