Advance Articles

General

An unusual chest lesion with dual pathologies

Jessica Colon, BS; Jay Nguyen, DO; Samuel Stahly, DO; Gulsun Erdag, MD; and Rajiv Nathoo, MD
The authors report the case of a 66-year-old male with a history of granuloma faciale (GF) and multiple basal cell carcinomas (BCCs) who presented with a pearly plaque on the chest. Biopsy revealed extrafacial GF with a coincidental BCC, representing a rare case of a collision tumor.
Advance Article
Public Health and Primary Care

The impact of adverse childhood experiences on age of diabetes diagnosis and associations with race and ethnicity

Allie Rice, BA; Madison Taylor, BS; Amy Hendrix-Dicken, PhD; Covenant Elenwo, DO; Julie Croff, PhD; Laura J. Chalmers, MD; Sara Coffey, DO; and Micah Hartwell, PhD
Previous research has linked the manifestation of multiple chronic diseases that are frequently due to health behaviors to adverse childhood experiences (ACEs). Despite this, the link between ACEs and the age of type 2 diabetes mellitus diagnosis is scarce. As such, our primary objective was to evaluate and describe the impact of ACEs on the age at diagnosis utilizing the data from the 2021 Behavioral Risk Factor Surveillance System.
Advance Article
Behavioral Health

The effectiveness of training student physicians in culturally sensitive patient care using an interprofessional culturally competent curriculum

Aida Aminpour, MA; McKenzie Gelvin, MA; Abigail Smurzynski, BS; Frank Gardner, PhD, ABPP; and Jeffrey Gardere, PhD, ABPP
This study aims to examine gaps in healthcare education by evaluating whether targeted cultural competency training leads to improvement in student physician preparedness to meet the needs of diverse populations.
Advance Article
NMM/OMT

The mechanism of muscle energy for a superiorly subluxed rib one

Katherine Teixeira, DO; Nicole Russell, DO; and Teodor Huzij, DO, FACN
The goal of this paper is to understand the true mechanism of the muscle energy technique for a superiorly subluxed rib treatment by outlining the treatment technique, involved structures, and other possible proposed mechanisms.
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Medical Education

The impact of a summer research internship program on research engagement of osteopathic medical students

Anupam Bishayee, MPharm, PhD; Michael A. Wallace, MMS, MS; Adam K. Bobak, BS; Tianna L. Sasher, BS; Luis A. Alvarez, DO; and Tania S. Flink, PhD
A summer research internship program was established in 2023 to improve research self-efficacy, facilitate research participation, and encourage lifelong research engagement in Doctor of Osteopathic Medicine (DO) students. The purpose of this study was to evaluate participant research experience and self-efficacy through pre- and postprogram surveys.
Advance Article
NMM/OMT

Effects of a myofascial and lymphatic osteopathic manipulative treatment protocol on mood and body connection: a randomized pilot study

Erika C. Levy, MS, DO; and Min-Kyung Jung, PhD
The objective of this study was to investigate the effects of a standardized myofascial and lymphatic OMT protocol on body awareness, dissociation, and mood symptoms related to anxiety, depression, and stress.
Advance Article
Musculoskeletal Medicine and Pain

Erratum to: Longitudinal outcomes among patients with fibromyalgia, chronic widespread pain, or localized chronic low back pain

John C. Licciardone, DO, MS, MBA; Elizabeth Brownell, BSEE; Uchechi Nwaichi, BS; Arpan Patel, BSA; and Khanh Do, BS
Advance Article
Public Health and Primary Care

Minimum physical activities protective against Alzheimer’s disease in late life: a systematic review

Amy Sakazaki, DO; Austin Lui, MS; Haneef Muhammad, MS; Claire Vu, MS; Aiden le Roux, BS; Patricia Lacayo, MS; and Shin Murakami, PhD, FGSA
Previous studies indicate an inverse relationship between physical activity (PA) and the risk of Alzheimer’s disease. This review aimed to evaluate existing literature to determine the effects of PA with an emphasis on late-life PA and the minimum levels of PA for older adults.
Advance Article
NMM/OMT

Effect of positional asymmetry palpatory models on improvement and retention of accuracy during pelvic asymmetry assessments

Justin M. Hajicek, BS; Madelyn B. Huhn, BS; Ashley Thurgood, MS; Edelheide N. Isemann, BS; Chase B. Barnwell, BA; Zane Starks, MS; Mary Ying-Fang Wang, PhD; and Brian F. Degenhardt, DO
Asymmetry of bony landmarks, such as the anterior superior iliac spine or posterior superior iliac spine, is often utilized to identify somatic dysfunction in the pelvis. However, establishing good accuracy for these assessments can be challenging, so objective training models have been developed to enhance learning and accuracy. The aim of this study was to determine the effect of training with positional asymmetry models with objective feedback on the improvement and retention of pelvic asymmetry assessment accuracy.
Advance Article
NMM/OMT

Ultrasound shear wave elastography to assess neck somatic dysfunction and OMT effects

Jing Gao, MD; Eliaz Lynch, BS; Michele Coleman, DO; John Moore, DO; David Park, DO; and Benjamin Wilde, DO
Osteopathic manipulative treatment (OMT) has been utilized in managing chronic neck pain and neck somatic dysfunction. However, osteopathic assessments lack quantitative measures to detect muscle abnormalities and evaluate the effect of OMT. This study aims to investigate the feasibility of utilizing ultrasound shear wave velocity and shear wave relative anisotropy coefficient to assess neck somatic dysfunction and the effect of OMT.
Advance Article
Clinical Image

Nailing the diagnosis

Milie M. Fang, DO; Lyudmyla Susla, BS; and Phoebe Rich, MD
Advance Article
General

Private equity in healthcare: implications and policy recommendations

Maxim Jestin, DO
Private equity (PE) involvement in healthcare has generated considerable debate regarding its implications for patient care, healthcare quality, and system sustainability. This Commentary provides an overview of both sides and offers policy recommendations addressing some of the detrimental effects of PE practices on the healthcare sector, to ensure that patient well-being remains the priority.
Advance Article
Medical Education

Race, ethnicity, and gender discrepancies between allopathic and osteopathic otolaryngology trainees from 2015 to 2023

Katrina M. Minutello, DO; Savannah L. Nicks, DO; Benjamin T. Gillette, DO; Md Sakibur Hasan, MS; and Carl B. Shermetaro, DO
Existing studies have analyzed gender and race representation among otolaryngology - head and neck surgery (OHNS) applicants and residents in the United States. Further analysis by graduate medical degree type does not currently exist. The objective of this study was to identify and compare gender and racial disparities in osteopathic and allopathic OHNS applicants and residents.
Advance Article
General

Geographical distribution and match trends of osteopathic residents in otolaryngology residency programs: a cross-sectional analysis

Luke Reardon, BS; Brenton Stucki, BS; Deepthi Akella, DO; and Michele M. Carr, DDS, MD, PhD
The objective of this study was to assess the geographical distribution, training site characteristics, and match patterns of osteopathic otolaryngology residents from 2020 to 2024, including relationships with medical school location and program history (historically AOA-accredited vs. historically allopathic-only).
Advance Article
Innovations

The utility of the implantable loop recorder in patients with Ehlers-Danlos syndrome and hypermobility spectrum disorder

Ermin Tale, DO; Grace Robinson, BS; Justin Edward, BS; Riya Kaushal, BA; Bernadette Riley, DO, MS; and Todd J. Cohen, MD
Patients with Ehlers-Danlos Syndrome (EDS) and hypermobility spectrum disorder (HSD) often complain of palpitations, presyncope/syncope, attributable to postural orthostatic tachycardia syndrome (POTS). This study aimed to evaluate the utility of implantable loop recorders in diagnosing and/or excluding arrhythmias not attributable to POTS in symptomatic patients with EDS and HSD.
Advance Article
NMM/OMT

Osteopathic manipulation to increase lactation quantity: a prospective case series

Eileen M. Conaway, DO; and Arlene E. O’Donnell, DO
There is currently no clinical research investigating the effect of osteopathic manipulation on the milk supply of lactating patients. Herbal and prescription galactagogues are limited and have the potential for serious side effects. The objective of this study was to determine whether OMT can increase milk supply in lactating people with low milk supply.
Advance Article
Medical Education

Interactive module’s effectiveness on empathy and attitudes of healthcare students

Jacob Linomaz, MHA; Desmond Chee, PA-C; Jana Wardian, PhD, MSW; Elizabeth Beverly, PhD; and Shelene Thomas, DPT, EDD, GCS, FNAP
This study investigates the role that virtual interactive modules play on osteopathic medical students and physician assistant students’ empathy and attitudes toward individuals with diabetes mellitus who are also affected by an array of social determinants of health.
Advance Article
Behavioral Health

Research gaps in the correlation of anxiety and depression prevalence in former college athletes: a systematic review

Madison L. Reese, BS; Blakelee A. Eggleston, BPH; Alexandra M. Smith, BS; Austin J. Young, BS; Anna Mazur, PhD, ABN, ABPP-CN; and Micah Hartwell, PhD
The transition from collegiate sports to life beyond athletics is a critical period marked by significant changes in identity, routine, and lifestyle. For many former athletes, these changes are compounded by mental health challenges, particularly depression and anxiety, which often go unaddressed during this pivotal phase. This review seeks to identify the existing research and gaps concerning the described supports in mental health, particularly depression and anxiety, in retired athletes.
Advance Article
Medical Education

Scholar 12 longitudinal outcomes: osteopathic research development application to facilitate scholarly activity during the pandemic and beyond

Marija J. Rowane, DO; Kevin A. Thomas, DO, MS; Travis M. Smith, DO, FAAEM; Mark A. Terrel, EdD; Michael P. Rowane, DO, MS, FAAFP, FAAO; and Robert W. Hostoffer, DO, LhD, MSMEd, MBA, FAAP, FACOP, FACOI, FCCP
This longitudinal study followed the research competency and scholarly product evolution of Scholar 12 — a free, interactive virtual platform designed for the osteopathic medical community — learners through consecutive academic years at a multi-campus COM, to demonstrate accessibility and application to all institutional remote learning needs during a pandemic and beyond.
Advance Article
Clinical Image

A swell case

Lauren Fill, DO; and Robert W. Hostoffer, DO
Advance Article
NMM/OMT

Effectiveness of osteopathic manual treatment in the elderly population: a scoping review of clinical evidence

Livio Molinari, DO; Luca Mingrone, DO; and Emanuele Novelli, DO
This scoping review evaluates the efficacy of OMT in elderly patients by analyzing selected studies that specifically explore its effects on balance, quality of life, and pain management.
Advance Article
Musculoskeletal Medicine and Pain

Chronic pain outcomes among patients treated by osteopathic vs. allopathic physicians: a 36-month follow-up study

John C. Licciardone, DO, MS, MBA; Hanna Lewis, BS; Kaylee Dahl, BS; Branden Adams, BS; and Subhash Aryal, PhD
This study aimed to compare the outcomes of patients with chronic low back pain treated by osteopathic and allopathic physicians in the United States utilizing a pragmatic design reflecting medical care in real-world settings, including an assessment of potential mediators of osteopathic medical care.
Advance Article
Medical Education

Incorporating the Certified Professional in Patient Safety credential into undergraduate medical curriculum: assessment and lessons learned

Lillee Gelinas, DNP, RN, CPPS; Amany K. Hassan, PhD; Janet Lieto, DO, FACOFP, CPPS; and Albert H. Yurvati, DO, PhD, CPPS
The objective of this study was to determine if the implementation of an advanced mandatory 2-week patient safety course, leading to the attainment of the Certified Professional in Patient Safety (CPPS™) credential, can yield a measurable impact on medical students’ patient safety knowledge entering into residency.
Advance Article
Obstetrics/Gynecology

Associations in fetal outcomes from cesarean sections with maternal comorbidities: a cross-sectional study of the Pregnancy Risk Assessment Monitoring System

Mackenzie Enmeier, DO; Elise Stephenson, DO; Jordyn Prince, DO; Caroline Markey, MD; Binh Phung, DO; and Micah Hartwell, PhD
The primary objective of this study was to determine the prevalence of negative fetal outcomes such as low birth weight, birth defects, prolonged hospital stay, and infant mortality in cesarean section deliveries and their increased risk of occurrence among mothers with comorbidities.
Advance Article
NMM/OMT

The epidemiology of osteopathic diagnoses and treatments in United States emergency departments from 2018 to 2021

Aviya Distefano, BS; Hanna Harris, MS; Kaitlin M. Bowers, DO; and Dhimitri A. Nikolla, DO, MS
Although a large proportion of US emergency physicians are osteopathic physicians, the frequency of osteopathic manipulative medicine (OMM) use in emergency departments (EDs) is unknown. The aim of this study was to estimate the frequency of OMM in EDs across the United States and describe the cohort who received OMM.
Advance Article
Clinical Image

Seatbelt sign

Ethan Nichols; Anjali Daniel; Latha Ganti, MD, MBA; and Michelle Wallen, DO
Advance Article
Behavioral Health

Medical student perceptions of psychiatric conditions and the impact of stigmatizing language

Zach Monahan, MS; Vivian Stevens, PhD; Micah Hartwell, PhD; and Alicia Ito Ford, PhD
The objectives of this survey were to evaluate the impact of stigmatizing language on medical students’ responses to case presentations of mental illnesses, and to determine how these perceptions vary across the course of medical education.
Advance Article
Cardiopulmonary Medicine

Corrigendum to: Comprehensive review of the heart failure management guidelines presented by the American College of Cardiology and the current supporting evidence

Lia Lazareva, BS; Jay H. Shubrook, DO; and Milind Dhond, MD, FACC
Advance Article
Clinical Image

TIF1-gamma associated dermatomyositis with extensive cutaneous involvement

Katherine M. Geric, BA; Hania S. Khan, BS; and Robert Dazé, DO, FAAD
Advance Article
Public Health and Primary Care

Emergency department wait times in concordance with blood alcohol content and subsequent alcohol use disorder

Sean Hayes, BA; Kaylee Mach, BS; Jennifer Briggs, DO; and Micah Hartwell, PhD
The authors of this study assess whether patients with a history of alcohol use disorder (AUD) and/or positive blood alcohol content (BAC+) affect emergency department (ED) wait times.
Advance Article
General

Geographical distribution of osteopathic urology residents and match trends in the United States

Ryan Wong, BS; Bebe Eke, BS; Andrew D. Vogel, MS; Bracken Burns, DO; and Kristen Conrad-Schnetz, DO
This study aimed to examine the number of DO graduates in urology residency programs over time and map their current distribution throughout the United States.
Advance Article
Medical Education

Corrigendum to: The predictive validity of MCAT scores and undergraduate GPA for COMLEX-USA licensure exam performance of students enrolled in osteopathic medical schools

Kenneth D. Royal, PhD, MSEd; Christian Meyer, BS; Erik Guercio, MA; Mark Speicher, PhD; Joseph Flamini, MBA; Jeanne M. Sandella, DO; Tsung-Hsun Tsai, PhD; and Cynthia A. Searcy, PhD
Advance Article
Pediatrics

Swelling and skin changes: an osteopathic approach to pediatric lymphedema management

Stephanie Jackson, BA; Afreen Hussaini, BS; Julisa Galan, BS; Tsz Chun Chung, BA; and Britani Javed, DO, FAAP
Pediatric lymphedema is a progressive condition of chronic swelling and soft-tissue damage, caused by impaired lymphatic function. The objective of this study was to systematically review and evaluate the evidence supporting the effectiveness of OMT in managing pediatric lymphedema and compare it to traditional therapies such as complex decongestive therapy.
Advance Article
Innovations

Assessing fundamental clinical skills of osteopathic medical students

John R. Boulet, PhD, FSSH; Jeanne M. Sandella, DO; John Gimpel, DO, MEd; and Richard LaBaere, DO, MPH
Based on the recommendations of the Special Commission on Osteopathic Medical Licensure Assessment, the NBOME established the Core Competency Capstone for Doctors of Osteopathic Medicine (C3DO). The objectives of this study were to describe the assessment and to ascertain the feasibility of administering it at multiple colleges of osteopathic medicine.
Advance Article
Cardiopulmonary Medicine

Signs and symptoms of vertebrobasilar insufficiency secondary to atherosclerosis: a systematic review

Chris Moors, BSc; and Claire Stapleton, PhD
The objectives of this study were to gather all relevant literature reporting features of vertebrobasilar insufficiency (VBI) pertaining to atherosclerosis, with the aim to help provide evidence that may guide clinical practice in the use of manual therapy interventions and to raise awareness of the manifestations that VBI may present.
Advance Article
Public Health and Primary Care

Use of a community care coordination team to reduce emergency department utilization and hospital readmissions for the highest utilizers

Stacia Shipman, DO; Kelly Painter, MD; Lindsey Claire Epperson, DO; and Keri Smith, DO
A small percentage of patients comprise a high proportion of healthcare utilization, particularly the costs associated with Emergency Department (ED) visits and inpatient hospitalization readmissions. The purpose of this study was to demonstrate a decrease in ED utilization and hospital readmissions in a selected group of super-utilizers post-intervention by a Community Care Coordination team and to determine cost avoidance.
Advance Article
General

DO (under) representation in US guideline development: an investigation of guideline authors from 2021–2023

Alfred B. Amendolara, MS; Steven Salazar, BSN; Tiffany Nguyen, BS; Porter Fife, BS; Blake Harris, BS; Alessandra M. Rivera, MS; Kennedy Madrid, BS; Yvannia Gray, BA; and Stephen Stacey, DO
Clinical guidelines are the backbone of evidence-based medical practice, shaping healthcare delivery and patient outcomes. To ensure that guidelines reflect the entire medical community, it is important that guideline-creation bodies have adequate representation from stakeholder groups with diverse viewpoints. To quantify the contribution of DOs to the body of literature guiding practice, author information was extracted from all US-based guidelines published in the years 2021, 2022, and 2023 listed in the ECRI Guidelines Trust database.
Advance Article
Musculoskeletal Medicine and Pain

Soft tissue manipulation enhances recovery of muscle mass in a disuse model of sarcopenia

Basil Mustaklem, BS; Mary Terry Loghmani, PhD, PT, MST, MTC; Abigail K. Waterfill, DPT; Mackenzie Caron, DPT; Daren A. Glore, BS; Nathaniel R. Meyer, BS; Luke D. Shelton, BS; Elicza A. Day, MS; Carmela Marciano, MS; Addison Gepfert, BS; Connor C. Wakefield, BS; Hailey Brown, BS; Sierra Street, MS, MS; Madeline M. Sasse, BS; Jacob Snyder, BS; Taylor Hiland, MS; Julia M. Hum, PhD; David C. Eland, DO; Tien-Min Gabe Chu, PhD, DDS; and Jonathan W. Lowery, PhD
Sarcopenia is a condition characterized by the age-related loss of muscle mass and function that diminishes physical capabilities and increases the risk of falls, fractures, and overall morbidity. In this study, the authors utilized a rat model of sarcopenia due to disuse atrophy and examined the effects of STM on recovery of muscle mass and regulation of pro-/anti-inflammatory cytokines.
Advance Article
Medical Education

A novel simulation enhanced education for osteopathic manipulation of hospitalized patients

Andrew P. Eilerman, DO, FACOFP; Gianna Libonate, DO; Sophia Pothen, DO; Melissa Rudie, DO; Shirley Zardoost, DO; Briana Donaldson, DO, FACOI; and Brad Gable, MD, MS, FACEP
Simulation-based medical education (SBME) is a method for enhancing learner skill prior to initiating care for real patients. This study aimed to determine the effectiveness of the SBME lab to enhance the training of medical learners of OMM on hospitalized patients.
Advance Article