Advance Articles

NMM/OMT

The role of osteopathic manipulative medicine in cerebral palsy: bridging treatment gaps and enhancing care

Ambrose Loc Ngo, MS; Niki Gharavi Alkhansari, BS; Rachana Tadakamalla, MS; Mercede Hess, MS; Uyen Tam Nguyen, BS; John Yazji, MS; and Robert S. Rogers, PhD
Osteopathic manipulative medicine (OMM) has gained attention as a complementary therapy for cerebral palsy-related symptoms. Techniques such as muscle stretching, gentle pressure, and joint manipulation have been shown to reduce muscle stiffness, alleviate stress, and enhance mobility in neuromuscular disorders. This narrative review synthesizes current evidence on OMM’s role in cerebral palsy management, with a focus on its application within the five models of osteopathic approach: behavioral, biomechanical, neurologic, metabolic, and respiratory-circulatory
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Pediatrics

Identifying somatic and social concerns that may suggest an underlying mental health condition in pediatric primary care

Casey Shubrook, MPH; Kimberly Breneisen, MD; and Maxine Pottenger, MD
Most adult mental health conditions begin in early childhood and adolescence, the most common being anxiety and behavioral disorders. Early intervention can improve outcomes and may reduce the risk of developing a clinical disorder in the future. However, children may not have the communication or understanding to share their symptoms with those around them, leaving pediatric primary care providers responsible for identifying concerning signs. This paper reviews both general symptoms that suggest possible mental health conditions as well as specific correlations between symptoms and psychiatric diagnoses.
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NMM/OMT

Osteopathic manipulative treatment in the management of headaches associated with musculoskeletal dysfunction: systematic review and meta-analysis

Yasir Rehman, MD, MSc; Jonathon Kirsch, DO; Mary Ying-Fang Wang, PhD; Robert Johnston, M.OMSc; Meadow Will, DO; Emily Gibson, DO; David Spencer, DO; Claudio Garcia, MLIS; and Karen T. Snider, DO
While previous review articles investigated the effectiveness of manual therapies for treating headaches, they did not focus specifically on OMT or perform a pooled meta-analysis to evaluate the effectiveness of outcomes. The aim of this study was to systematically evaluate the effectiveness of OMT for managing headaches associated with musculoskeletal dysfunction and to assess the associated harm outcomes.
Advance Article
Medical Education

A quantitative analysis comparing pre-clinical volunteering hours with third-year medical students’ preceptor evaluations

Emily K. Ranta, DO; Joshua C. Ranta, DO; David Redden, PhD; and Alexis M. Stoner, PhD, MPH
Many studies have suggested that participation in pre-clerkship volunteering opportunities is associated with higher confidence in clinical skills, improved perspectives on social barriers, and greater soft skills and empathy. he aim of this study was to explore the relationship between volunteer hours and third-year evaluations, with the hypothesis being that these previously studied, perceived benefits of volunteerism would translate to better evaluations.
Advance Article
Obstetrics/Gynecology

Predictability of cranial base strains as related to birth presentation: a review of literature

Summer K. McElwain, BS; and Deborah Schmidt, DO
The etiology of cranial base strains (CBS) in newborns is poorly elucidated in historical and current literature. There have been few studies examining the prevalence of CBS in newborns or vaginal birth presentation prevalence individually, let alone their relationship. The objective of this review was to consolidate all historical and current research on the potential link between vaginal birth presentation and CBS in infants.
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Behavioral Health

Corrigendum to: Exploring the impact of methylenetetrahydrofolate reductase (MTHFR) gene variations on autism spectrum disorder severity

Christian C. Iannuzzelli, BS; Andrea L. Iannuzzelli, DO; Brandon Cunha, BS; Venkateswar Venkataraman, PhD; Wendy Aita, PhD; and Jennifer LeComte, DO
Advance Article
NMM/OMT

Osteopathic manipulative treatment for refractory chronic traumatic pain and mobility restrictions at a level 1 trauma center

Gerard A. Baltazar, DO, FACOS, FACS, OMT; Michelle Cao, MD; Jared Van Vleet, BS; Sky Hart, BS; Andrea Jakubowski, BS; Nathan Suree, BS; Patrizio Petrone, MD, PhD, MPH, FACS, MAMSE; Shahidul Islam, DrPH, MPH; Francisco Machado, RN; and Jerry Rubano, MD, FACS
Traumatic musculoskeletal injuries may result in chronic pain and mobility limitations, decreasing quality of life, and increasing predisposition to comorbid disorders. The objective of this study was to detail the potential benefits of utilizing OMT in a trauma outpatient program for the care of injured patients suffering from chronic pain and mobility limitations.
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Clinical Image

Painful and exophytic tumor on the thigh

Milie M. Fang, DO; Kevin P. White, MD; and Alex G. Ortega-Loayza, MD, MCR
Advance Article
Public Health and Primary Care

Characterizing traumatic brain injury in unsheltered homelessness: prevalence of TBI and cognitive sequelae in individuals utilizing street medicine

Graham Atkin, PhD; Jessica Reece, MA; and Isabel Moran, BS
People experiencing homelessness are at a disproportionately greater risk for developing traumatic brain injury (TBI) than the general population. There has been minimal research to evaluate the prevalence of TBI or the long-term cognitive impacts of TBI among the population experiencing homelessness within the US. This study aimed to assess primarily whether those experiencing unsheltered homelessness had a higher prevalence of TBI than those in shelter.
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Clinical Image

Cutaneous manifestations of Addison’s disease

Christy Lu, DO; Dominique Jacobs, DO; Stacey Blannett, DO; Ranita E. Kuryan, MD; and Shane M. Swink, DO, MS
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Musculoskeletal Medicine and Pain

Do patients with renal calculi exhibit viscerosomatic reflexes as evident on CT imaging?

Dillon R. Haughton, DO; Akhil K. Gupta, DO; Bader R. Nasir, BS; and Adrienne M. Kania
Experimental evidence supporting the existence of the viscerosomatic reflex highlights an involvement of multiple vertebral levels when renal pathology is present. Further exploration of this reflex, particularly in the context of nephrolithiasis, could offer valuable insights for osteopathic treatments related to this pathology. This study aimed to compare the rotation of vertebrae at levels associated with the viscerosomatic reflex in renal pathology in patients with nephrolithiasis vs. those without kidney stones.
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Medical Education

Predicting COMLEX-USA Level 2-CE using medical school performance and use for student advising

Shiyuan Wang, PhD; and Pamela Basehore, MPH, EdD
The purpose of this study is to: (1) evaluate the predictive value of major performance measures from preadmission to the clerkship years on COMLEX-USA Level 2-CE, including the new COMLEX-USA Level 1 pass/fail only scoring and the less-studied COMSAE Phase 2 to establish a predictive model; and (2) identify optimal cutoff scores of strong predictors to advise students on their preparation of Level 2-CE.
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NMM/OMT

Evaluating the acute effect of osteopathic manipulative treatment on sprint performance in young adults

Garrick Quackenbush; Arielle Navarro, BS; Dresdan Quackenbush, BS; Catherine Arnold, BS; Kalin Sorenson, BS; Kodi Jo McKinlay, BS; Andrew Jacob Roush, DO; and Cory Cosgrave, DO
Osteopathic manipulative treatment (OMT) has been shown to improve athletic performance by enhancing shoulder range of motion, flexibility, and balance in various sports. The present study aims to investigate the effects of OMT, with a focus on muscle energy technique, and its subsequent impact on sprinting performance in young adults.
Advance Article
Letters to the Editor

Expanding the role of OMT in chronic rhinosinusitis: a welcome step forward

James R. Burmeister, BS
Advance Article
Innovations

Artificial intelligence and osteopathic medicine: preserving human-centered care in an era of technological advancement

Ryan Newhardt, DO; Michalah O’Connell, DO; May S. Lin, DO; and Natasha N. Bray, DO
As healthcare transforms with artificial intelligence (AI) tools offering enhanced diagnostic capabilities, predictive analytics, and administrative efficiency, there is a risk that overreliance on empirical data may undermine the osteopathic patient care. This commentary examines how physicians can ethically integrate AI systems while preserving osteopathic medicine’s humanistic core.
Advance Article
General

Necrobiosis lipoidica arising in a port wine stain treated with topical ruxolitinib

Neena Edupuganti, DO; Jay Nguyen, DO; Fahad Siddiqui, DO; Victoria Dukharan, MD; and Rajiv Nathoo, MD
Necrobiosis lipoidica (NL) is a rare chronic granulomatous disease that is historically associated with diabetes mellitus. The exact etiology and pathogenesis are not fully understood; however, microangiopathy is believed to be a contributing factor. NL classically manifests as erythematous papules that coalesce into plaques commonly localized to the lower extremities. The authors present a case of NL arising within a port-wine stain, in which the NL was successfully treated with topical ruxolitinib monotherapy.
Advance Article
Cardiopulmonary Medicine

Retrospective analysis of patients with cardiopulmonary symptoms in the setting of Long COVID syndrome: investigating risk factors

Jenna Mahoney, DO; Genti Shatri, DO; Patricia E. Simmer, MD; Daniel Doherty, MD; Vamsi Matta, DO; and Dominic J. Valentino, III, DO, FCCP
Long COVID, a debilitating condition characterized by persistent symptoms following acute SARS-CoV-2 infection, continues to pose a significant public health burden. Currently, research is ongoing regarding risk factors for developing Long COVID. The objectives of this study are to evaluate a cohort of patients who followed up in the Long COVID clinic who were experiencing cardiopulmonary symptoms 8–12 weeks from initial inoculation, and to retrospectively identify any statistically significant risk factors or clinical features present.
Advance Article
Medical Education

Dermatology match disparities: analyzing osteopathic vs. allopathic student outcomes post-ACGME/AOA single accreditation system (2020–2024)

Leo Wan, DO; Karandeep Bawa, BS; Aileen Park, BS; Haaris Kadri, BA; Austin Cusick, DO; and Shannon C. Trotter, DO
Dermatology remains one of the most competitive medical specialties, with successful candidates often demonstrating outstanding academic performance, extensive research experience, and strong letters of recommendation. This study examines the differences in DO and MD match rates following the single graduate medical education accreditation system, focusing on the match performance of DO dermatology applicants.
Advance Article
NMM/OMT

Why don’t more physicians use osteopathic manipulative medicine? A cross-sectional study of utilization and referral barriers

Stephen K. Stacey, DO, FAAFP; Anthony Furlano, DO; Joanne Genewick, DO; Erin Westfall, DO; Bryan Gordon, DO; and Jiwan Toor, DO
Evidence supports osteopathic manipulative medicine (OMM) as an effective manual therapy, although it remains underutilized by Doctors of Osteopathic Medicine (DOs). Understanding barriers preventing the broader adoption of OMM is essential to expanding access to it as a noninvasive treatment option, so the authors of this paper surveyed both DOs and non-DO clinicians to identify perceived barriers to OMM.
Advance Article
Medical Education

Technology use and satisfaction among colleges/schools of osteopathic medical education

Machelle Linsenmeyer, EdD; and Lance Ridpath, MS
In March 2020, as the COVID-19 pandemic became a national concern, the world of medical education was greatly tested and institutions had to act quickly to account for current capacities and enact rapid changes to meet the needs of faculty, staff, and students. This paper provides an essential comparison of the technology landscape at the COMs from when the COVID-19 pandemic hit to now.
Advance Article
NMM/OMT

Why is identification with osteopathy decreasing in medical students?

Zachary S. Kauffman, BA; Tony Harper, PhD; Robert A. Augustyniak, PhD; and Chloe Ruff, PhD
Survey data reveal a decrease in osteopathic medical students’ identification with osteopathy, which is what distinguishes an osteopathic physician’s values, attitudes, and commitment to the tenets of osteopathy. This study aims to determine factors that influence a student’s identification with osteopathy and to precisely quantify these factors’ predictive effect on osteopathic identification while simultaneously controlling for other possibly confounding factors.
Advance Article
Musculoskeletal Medicine and Pain

Does forward head posture correction improve temporomandibular joint dysfunction? A pilot randomized trial using a cervical extension traction orthotic

Shima A. Mohammad Zadeh, MSc, PT; Tamer Shousha, PhD, PT; Ibrahim M. Moustafa, PhD, PT; Iman Khowailed, DSc, PT; and Deed E. Harrison, DC
Temporomandibular disorders (TMDs) have a high prevalence ranging between 15 and 25 % among young adults and adults globally. The primary objective of this study was to investigate the additional effect of forward head posture correction by a cervical extension traction orthotic on myogenic TMD symptoms of pain and function.
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General

Equity reporting in systematic reviews and meta-analysis for geographic atrophy: a PROGRESS-Plus assessment

Ryan Emmert, BS; Tyler McKenzie, BS; Dawsyn Smith, BS; Hanna Russell; Gracie Schultheis, BS; and Micah Hartwell, PhD
Systematic reviews and meta-analyses (SRMAs) are crucial for treatment development, and they must provide guidelines that represent diverse patient demographics to promote equitable health care. As new research and treatment modalities are being developed for geographic atrophy, establishing an equitable research foundation is vitally important to physicians as they personalize their treatment plans. This analysis aims to determine whether SRMAs pertaining to geographic atrophy are reporting equity-related items utilizing the PROGRESS-Plus framework.
Advance Article
Behavioral Health

Exploring the impact of methylenetetrahydrofolate reductase (MTHFR) gene variations on autism spectrum disorder severity

Christian C. Iannuzzelli, BS; Andrea L. Iannuzzelli, DO; Brandon Cunha, BS; Venkateswar Venkataraman, PhD; and Wendy Aita, PhD
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by challenges in social communication and repetitive behaviors. This study investigates whether MTHFR activity levels correlate with the severity of ASD, aiming to enhance our understanding of the genetic factors that influence ASD severity and potentially inform more targeted therapeutic approaches.
Advance Article
Innovations

A proven template for providing streamlined, scalable, cost-effective clinical research opportunities in osteopathic medical schools

Jacey N. Greek, BS; Andrew P. Greek, BS; Mari Hopper, MS, PhD; and Robert Arnce, MD
Clinical research plays a crucial role in advancing medical knowledge and contributing to the resume of medical students attempting to match into a residency, so the creation of sustainable and effective research opportunities within medical education is paramount. The authors describe a template that they've created to assist osteopathic medical students conduct streamlined, scalable, and cost-effective clinical research at their institution, which they believe can be implemented at other COMs.
Advance Article
Clinical Image

Erythromelalgia: a cutaneous manifestation of polycythemia vera

Mark Saad, BS; and Robert Dazé, DO, FAAD
Advance Article
General

The hospitalist’s paradox: on pay, perception, and the true value of a healer in the valley of the sun

Gary P. MacDonald, DO, MS, FAAFP
This commentary examines the sentiments of a Phoenix-area hospitalist who feels underpaid despite earning an objectively high salary. The article concludes that true professional value transcends monetary figures, calling for systemic changes to better acknowledge and support physicians while ensuring their profound contributions are recognized beyond financial metrics.
Advance Article
Public Health and Primary Care

Comparative cross-sectional analysis of asthma outcomes and sinus surgery utilization in Appalachian and non-Appalachian counties of Ohio

Samuel Borgemenke, BS; Robert Osap, BS; Kirsten Bogunovich, BS; Nicholas Durstock, BS; and Elizabeth A. Beverly, PhD
The purpose of this study was to compare the effects of social determinants of health on the prevalence and treatment of asthma in Appalachian vs. non-Appalachian regions of Ohio, and how those factors affect the rate at which sinus surgery is performed in different populations.
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General

An unusual chest lesion with dual pathologies

Jessica Colon, BS; Jay Nguyen, DO; Samuel Stahly, DO; Gulsun Erdag, MD; and Rajiv Nathoo, MD
The authors report the case of a 66-year-old male with a history of granuloma faciale (GF) and multiple basal cell carcinomas (BCCs) who presented with a pearly plaque on the chest. Biopsy revealed extrafacial GF with a coincidental BCC, representing a rare case of a collision tumor.
Advance Article
Public Health and Primary Care

The impact of adverse childhood experiences on age of diabetes diagnosis and associations with race and ethnicity

Allie Rice, BA; Madison Taylor, BS; Amy Hendrix-Dicken, PhD; Covenant Elenwo, DO; Julie Croff, PhD; Laura J. Chalmers, MD; Sara Coffey, DO; and Micah Hartwell, PhD
Previous research has linked the manifestation of multiple chronic diseases that are frequently due to health behaviors to adverse childhood experiences (ACEs). Despite this, the link between ACEs and the age of type 2 diabetes mellitus diagnosis is scarce. As such, our primary objective was to evaluate and describe the impact of ACEs on the age at diagnosis utilizing the data from the 2021 Behavioral Risk Factor Surveillance System.
Advance Article
Behavioral Health

The effectiveness of training student physicians in culturally sensitive patient care using an interprofessional culturally competent curriculum

Aida Aminpour, MA; McKenzie Gelvin, MA; Abigail Smurzynski, BS; Frank Gardner, PhD, ABPP; and Jeffrey Gardere, PhD, ABPP
This study aims to examine gaps in healthcare education by evaluating whether targeted cultural competency training leads to improvement in student physician preparedness to meet the needs of diverse populations.
Advance Article
NMM/OMT

The mechanism of muscle energy for a superiorly subluxed rib one

Katherine Teixeira, DO; Nicole Russell, DO; and Teodor Huzij, DO, FACN
The goal of this paper is to understand the true mechanism of the muscle energy technique for a superiorly subluxed rib treatment by outlining the treatment technique, involved structures, and other possible proposed mechanisms.
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Medical Education

The impact of a summer research internship program on research engagement of osteopathic medical students

Anupam Bishayee, MPharm, PhD; Michael A. Wallace, MMS, MS; Adam K. Bobak, BS; Tianna L. Sasher, BS; Luis A. Alvarez, DO; and Tania S. Flink, PhD
A summer research internship program was established in 2023 to improve research self-efficacy, facilitate research participation, and encourage lifelong research engagement in Doctor of Osteopathic Medicine (DO) students. The purpose of this study was to evaluate participant research experience and self-efficacy through pre- and postprogram surveys.
Advance Article
NMM/OMT

Effects of a myofascial and lymphatic osteopathic manipulative treatment protocol on mood and body connection: a randomized pilot study

Erika C. Levy, MS, DO; and Min-Kyung Jung, PhD
The objective of this study was to investigate the effects of a standardized myofascial and lymphatic OMT protocol on body awareness, dissociation, and mood symptoms related to anxiety, depression, and stress.
Advance Article
Public Health and Primary Care

Minimum physical activities protective against Alzheimer’s disease in late life: a systematic review

Amy Sakazaki, DO; Austin Lui, MS; Haneef Muhammad, MS; Claire Vu, MS; Aiden le Roux, BS; Patricia Lacayo, MS; and Shin Murakami, PhD, FGSA
Previous studies indicate an inverse relationship between physical activity (PA) and the risk of Alzheimer’s disease. This review aimed to evaluate existing literature to determine the effects of PA with an emphasis on late-life PA and the minimum levels of PA for older adults.
Advance Article
General

Private equity in healthcare: implications and policy recommendations

Maxim Jestin, DO
Private equity (PE) involvement in healthcare has generated considerable debate regarding its implications for patient care, healthcare quality, and system sustainability. This Commentary provides an overview of both sides and offers policy recommendations addressing some of the detrimental effects of PE practices on the healthcare sector, to ensure that patient well-being remains the priority.
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Medical Education

Race, ethnicity, and gender discrepancies between allopathic and osteopathic otolaryngology trainees from 2015 to 2023

Katrina M. Minutello, DO; Savannah L. Nicks, DO; Benjamin T. Gillette, DO; Md Sakibur Hasan, MS; and Carl B. Shermetaro, DO
Existing studies have analyzed gender and race representation among otolaryngology - head and neck surgery (OHNS) applicants and residents in the United States. Further analysis by graduate medical degree type does not currently exist. The objective of this study was to identify and compare gender and racial disparities in osteopathic and allopathic OHNS applicants and residents.
Advance Article
Innovations

The utility of the implantable loop recorder in patients with Ehlers-Danlos syndrome and hypermobility spectrum disorder

Ermin Tale, DO; Grace Robinson, BS; Justin Edward, BS; Riya Kaushal, BA; Bernadette Riley, DO, MS; and Todd J. Cohen, MD
Patients with Ehlers-Danlos Syndrome (EDS) and hypermobility spectrum disorder (HSD) often complain of palpitations, presyncope/syncope, attributable to postural orthostatic tachycardia syndrome (POTS). This study aimed to evaluate the utility of implantable loop recorders in diagnosing and/or excluding arrhythmias not attributable to POTS in symptomatic patients with EDS and HSD.
Advance Article
Behavioral Health

Research gaps in the correlation of anxiety and depression prevalence in former college athletes: a systematic review

Madison L. Reese, BS; Blakelee A. Eggleston, BPH; Alexandra M. Smith, BS; Austin J. Young, BS; Anna Mazur, PhD, ABN, ABPP-CN; and Micah Hartwell, PhD
The transition from collegiate sports to life beyond athletics is a critical period marked by significant changes in identity, routine, and lifestyle. For many former athletes, these changes are compounded by mental health challenges, particularly depression and anxiety, which often go unaddressed during this pivotal phase. This review seeks to identify the existing research and gaps concerning the described supports in mental health, particularly depression and anxiety, in retired athletes.
Advance Article
Musculoskeletal Medicine and Pain

Chronic pain outcomes among patients treated by osteopathic vs. allopathic physicians: a 36-month follow-up study

John C. Licciardone, DO, MS, MBA; Hanna Lewis, BS; Kaylee Dahl, BS; Branden Adams, BS; and Subhash Aryal, PhD
This study aimed to compare the outcomes of patients with chronic low back pain treated by osteopathic and allopathic physicians in the United States utilizing a pragmatic design reflecting medical care in real-world settings, including an assessment of potential mediators of osteopathic medical care.
Advance Article