Public Health and Primary CareCASE REPORT

Topical Imiquimod and Subsequent Erythema Multiforme

Luke Maxfield, DO; David Gaston, MD; Aurora Peck, BS; and Katrina Hansen, DO
Notes and Affiliations
Notes and Affiliations

Received: February 19, 2019

Accepted: March 1, 2019

Published: December 16, 2019

J Osteopath Med; 120(1): 45-48

Topical imiquimod is commonly used in the nonsurgical management of actinic keratosis and superficial basal cell carcinoma. Although adverse effects have been limited primarily to local irritation, another rare adverse reaction is erythema multiforme. We present a case of erythema multiforme involving the oral mucosa, trunk, and extremities that followed broad application of topical imiquimod for the management of suspected superficial basal cell skin cancers and actinic keratosis. The patient had used imiquimod previously without complication. Cessation of use and systemic corticosteroids resulted in prompt clearance.

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